Supplement based on same, silibinin, vitamin B6 and other nutrients such as milk thistle, which contributes to the normal maintenance of the liver. The standardized extract of milk thistle seeds has properties of protection and promotion of protein synthesis of hepatocytes, a mechanism for the regeneration of liver cells. It stimulates the flow of bile acids, the production of bile salts and helps protect liver tissue. The powdered extract obtained from the leaves of a specific variety of artichokes has been selected for its high concentration of biophenols and flavonoids.